After being born in England, Genelia studied at Apostolic Carmel High School in Bandra, Mumbai. After school, she joined the St. Andrews College,
Bandra to pursue a Bachelor's Degree. Mumbai-based Genelia starred in the big budgeted Boys by top director Shankar. She starred opposite fellow
débutante Siddharth. The film was a box-office hit and launched her career.
She left Kollywood for a while to concentrate on the Tollywood industry, starring in other successful films including, Satyam, Masti, Samba and Sye. She followed it up with a pairing with popular actress Shriya in Subhash Chandra Bose. She returned to the Tamil industry with the hit, Sachein with Vijay.
Her film, Happy opposite Allu Arjun was a hit.
Her most recent film, Bommarillu, with Siddharth Narayan, is a super hit.
Chennai Kadhal, her Tamil project did average business. She was also a part of Mani Ratnam's stage show, Netru, Indru, Naalai.